Skin, hair & tanning
SNAP8: published research
Also known as Acetyl octapeptide-3
An eight-amino-acid cosmetic peptide that resembles part of SNAP-25, a protein nerve endings need to release signals to muscle. It is studied in skin-care formulas for its effect on expression lines.
Evidence at a glance
2 studies 2020–2024
- 2 Human trial
What researchers look at
- Expression lines
- Skin care
- SNARE complex
- Topical use
What is still unknown
Published human studies are small and short, and test it mixed with other ingredients.
Studies in people
2- Human trial
In 24 healthy adults over 28 days, an eye-area patch containing acetyl octapeptide-3 with other actives improved wrinkles and elasticity; effects cannot be attributed to SNAP-8 alone.
Shin JY, et al. Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities. Annals of Dermatology. 2024. PMID 39082657
- Human trial
In a 12-week single-centre study in adults, a multi-ingredient microneedle patch including acetyl octapeptide-3 (SNAP-8) reduced fine lines and improved hydration; effects cannot be attributed to SNAP-8 alone.
Avcil M, et al. Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study. Journal of Cosmetic Dermatology. 2020. PMID 31134751
Short summaries of published studies, with links to the original papers. Results in animals or cells may not apply to people. This is not medical advice and not a guide to use.