Tanning
Melanotan II
The pigmentation peptide
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Melanotan II 10 mg · +AED 585 each
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Kisspeptin 10 mg
AED 730
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A synthetic analogue of the hormone that regulates melanin production. Studied for its action on melanocortin receptors, the signalling route behind skin pigmentation.
Research use only. Supplied for laboratory and analytical research. Not a medicine or supplement, and not for human or animal use. We don't give dosing or clinical advice. Read the terms
- Presentation
- Lyophilised powder, reconstituted — 3 mL pen
Manufactured under controlled research-grade conditions. For documentation or questions about this compound, contact us on WhatsApp.
Published research
- Human trial
In a small single-blind, placebo-controlled pilot phase I study in three healthy men, melanotan II increased skin pigmentation; nausea, stretching/yawning and spontaneous erections were reported.
Dorr RT, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sciences. 1996. PMID 8637402
- Human trial
In a double-blind, placebo-controlled crossover study in ten men with psychogenic erectile dysfunction, melanotan II initiated erections in eight; transient nausea, yawning and reduced appetite occurred.
Wessells H, et al. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study. Journal of Urology. 1998. PMID 9679884
- Human trial
In a double-blind, placebo-controlled crossover study in ten men with organic erectile dysfunction, melanotan II initiated erections and raised reported sexual desire; nausea was more frequent than placebo.
Wessells H, et al. Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology. 2000. PMID 11018622
- Animal study
In OLETF rats, a model of obesity and type 2 diabetes, Melanotan-II infused under the skin reduced food intake and body weight, increased insulin sensitivity versus freely fed and pair-fed rats, and improved glucose tolerance.
Banno R, et al. The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats. Peptides. 2004. PMID 15350695
- Animal study
In male rats, 7-day brain infusion of Melanotan-II briefly suppressed feeding and reduced fat-pad weight; co-infused with neuropeptide Y (NPY), it curbed NPY-driven overeating, fat gain, and insulin and leptin rises, but not NPY's suppression of reproductive and growth-hormone axes.
Raposinho PD, et al. The melanocortin agonist Melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat. Journal of Neuroendocrinology. 2003. PMID 12535159
- Animal study
In male rats under chronic unpredictable stress, daily Melanotan-II injections (tested in a separate group from Semax) reversed or reduced stress-induced anhedonia, adrenal enlargement, loss of hippocampal BDNF and slowed weight gain; forced-swim immobility was unaffected.
Inozemtseva LS, et al. Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress. European Journal of Pharmacology. 2024. PMID 39442746
Short summaries of published studies, with links to the original papers. Results in animals or cells may not apply to people. This is not medical advice and not a guide to use.
All research on Melanotan II